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OCR: oblasts is under The activity of osteoclasts an nd local factors, the control of systemic horm teoclastic activity Systemic hormones that con roxyvitamin D. are PTH, calcitonin, and 1,25- stimulate PTH and 1,25-dihydroxyvitar calcitonin osteoclasts to resorb bone, wh ocal factors inhibits the activity of osteoc une cells in the produced by bone cells and by imulating marrow cavity are also capab such as osteoclasts; these include cyto is factor (TNF), interleukin-1 (IL-1), tumour ly of osteoblasts ulate the activity and interleukin-6 (IL-6). The is also regulated by factors th of osteoclas